The effective dose of butorphanol tartrate in patients of different ages undergoing painless gastroscopy.

OBJECTIVE

This study evaluated the 50% effective dose (ED50) and 95% effective dose (ED95) of butorphanol tartrate in patients undergoing painless gastroscopy.

METHODS

Patients who underwent painless gastroscopy at Binzhou Medical University Hospital were divided into the youth, middle-aged, and older groups. The ED50 and ED95 required for successful sedation using butorphanol tartrate were measured using the Dixon up-and-down method in patients in the different age groups. Patients in each group were administered intravenous butorphanol 5 minutes before gastroscopy. Each patient was administered 2 mg/kg propofol. The ED50 and ED95 of butorphanol were calculated using probit analysis.

RESULTS

In total, 95 patients were included. The ED50s of butorphanol in the youth, middle-aged, and older groups were 7.384, 6.657, and 6.364 μg/kg, respectively. The ED95s of butorphanol doses in these groups were 9.108, 8.419, and 7.348 μg/kg, respectively.

CONCLUSIONS

The ED50 and ED95 varied among the age groups, indicating that the effective dose decreases with age.