Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010
Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia.
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Donohoe Gary, Frodl Thomas, Morris Derek, Spoletini Ilaria, Cannon Dara M, Cherubini Andrea, Caltagirone Carlo, Bossù Paola, McDonald Colm, Gill Michael, Corvin Aiden P, Spalletta Gianfranco
Аннотация
A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.
Предметные рубрики MeSH
AdultAnalysis of VarianceBrain MappingCarrier ProteinsDysbindinDystrophin-Associated ProteinsElectroencephalographyFemaleGenetic Predisposition to DiseaseHaplotypesHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory DisordersMemory, Short-TermMiddle AgedNeuropsychological TestsOccipital LobePrefrontal CortexPsychiatric Status Rating ScalesSchizophrenia