[Hyperparathyroidism and its management].

Hyperparathyroidism (HPT), resulting from the excess of endogenous parathyroid hormone is cited as one of diseases which cause secondary osteoporosis. HPT consists of primary (1 degree) and secondary (2 degrees) HPT, resulting mainly from chronic renal failure (CRF). HPT is easily distingishable from primary osteoporosis by biochemical measurements. Parathyroidectomy (PTX) is the only option available for the radical cure of 1 degree HPT and more than 10% increase in bone mass occurs after PTX. On the other hand, dietary phosphorus restriction, phosphorus binders, active vitamin D3 metabolites are useful for 2 degrees HPT due to CRF. When these treatments are not effective to inhibit PTH secretion adequately, oral active vitamin D3 pulse therapy, PTX and percutaneous ethanol injection therapy should be considered.