Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 1997
Some characteristics of primary hyperparathyroidism in Vietnamese immigrants living in Southern California.
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Luong K V, Nguyen L T
Аннотация
OBJECTIVE: To characterize primary hyperparathyroidism (PHP) in Vietnamese immigrants living in southern California and to summarize the results of treatment.
METHODS: We describe 11 patients (8 women and 3 men) with a mean age of 57.91 years who underwent follow-up from 1991 to 1995 after PHP was diagnosed. The patients had no specific complaints. Four patients had a history of kidney stones, and five had chronic hypertension. Only five patients had high levels of total serum calcium; the other six patients had normal or fluctuating levels of total serum calcium. All patients, however, had high levels of intact parathyroid hormone (PTH) and ionized calcium. Preoperatively, parathyroid imaging with technetium-99m sestamibi demonstrated persistently increased parathyroid gland uptake.
RESULTS: In all nine patients who underwent surgical treatment, an adenoma was found in the parathyroid glands; two patients refused operative intervention. The mean serum phosphate was in the low-normal range and increased postoperatively (2.70 versus 3.52 mg/dL; P<0.001). The mean serum chloride level also decreased postoperatively (104.62 versus 100.78 mEq/L; P<0.001). The ratio of chloride/phosphate decreased significantly after adenoma removal (39.44 versus 29.21; P<0.001). Six patients received calcium gluconate either alone or in combination with vitamin D supplements for hypocalcemia postoperatively. The other three patients, however--who did not receive calcium supplements postoperatively--had persistently high levels of intact PTH but normal serum Ca++ levels and subsequently were treated effectively with calcium gluconate and vitamin D.
CONCLUSION: The presence of hypercalcemia, especially Ca++, and an increased level of intact PTH establishes the diagnosis of PHP. After parathyroidectomy, the persistence of high levels of intact PTH in association with normal serum Ca++ suggested the presence of secondary hyperparathyroidism, which was treated effectively with calcium gluconate and vitamin D. These patients had the same clinical picture as other ethnic groups with PHP, but they needed either calcium alone or calcium and vitamin D supplements after parathyroidectomy because of their bone loss from prolonged PHP.
METHODS: We describe 11 patients (8 women and 3 men) with a mean age of 57.91 years who underwent follow-up from 1991 to 1995 after PHP was diagnosed. The patients had no specific complaints. Four patients had a history of kidney stones, and five had chronic hypertension. Only five patients had high levels of total serum calcium; the other six patients had normal or fluctuating levels of total serum calcium. All patients, however, had high levels of intact parathyroid hormone (PTH) and ionized calcium. Preoperatively, parathyroid imaging with technetium-99m sestamibi demonstrated persistently increased parathyroid gland uptake.
RESULTS: In all nine patients who underwent surgical treatment, an adenoma was found in the parathyroid glands; two patients refused operative intervention. The mean serum phosphate was in the low-normal range and increased postoperatively (2.70 versus 3.52 mg/dL; P<0.001). The mean serum chloride level also decreased postoperatively (104.62 versus 100.78 mEq/L; P<0.001). The ratio of chloride/phosphate decreased significantly after adenoma removal (39.44 versus 29.21; P<0.001). Six patients received calcium gluconate either alone or in combination with vitamin D supplements for hypocalcemia postoperatively. The other three patients, however--who did not receive calcium supplements postoperatively--had persistently high levels of intact PTH but normal serum Ca++ levels and subsequently were treated effectively with calcium gluconate and vitamin D.
CONCLUSION: The presence of hypercalcemia, especially Ca++, and an increased level of intact PTH establishes the diagnosis of PHP. After parathyroidectomy, the persistence of high levels of intact PTH in association with normal serum Ca++ suggested the presence of secondary hyperparathyroidism, which was treated effectively with calcium gluconate and vitamin D. These patients had the same clinical picture as other ethnic groups with PHP, but they needed either calcium alone or calcium and vitamin D supplements after parathyroidectomy because of their bone loss from prolonged PHP.