[Gastric juice levels of nitric oxide in relation to gastric acidicity in patients with upper digestive tract diseases].

The purpose of the investigation was to study a correlation between gastric secretory function and the gastric juice levels of nitric oxide (NO) in patients with upper digestive tract diseases. One hundred and seventy-four patients with upper digestive tract diseases were examined to solve the set tasks. Analysis of the correlation between gastric juice NO levels and gastric secretion volume in patients with gastroduodenal diseases indicated that no correlation was found in the level of end products of gastric juice NO metabolism and total acidity as an aggression factor. At the same time, there was a positive correlation between the gastric juice of NO and the volume of basal and stimulated gastric secretion. Since during gastric juice secretion, blood supply of the gastric mucosal is increased due its dilated microvessels, NO is most likely to cause dilatation and accordingly a gastric secretion stimulant. Therefore, by taking into account that provision of sufficient gastric mucosal blood supply is one of the protective means in gastroduodenal diseases, it may be suggested that in this case NO performs a positive role, by participating in gastric protection.