An update on the genetics of Gilles de la Tourette syndrome.

OBJECTIVES

To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic.

METHODS

The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized.

RESULTS AND

CONCLUSIONS

There is considerable data that suggests that: (1). genetic factors play an important role in the manifestation of GTS; (2). several genes are important with some possibly having major effect; and (3). several regions of the genome have been identified as potential locations of these susceptibility genes.