Public perceptions of polygenic testing and embryo selection for non-medical traits.

Some advances in reproductive technologies raise substantial ethical and psychological challenges, for example, the use of preimplantation genetic testing to select embryos based on non-medical traits. While studies have explored public willingness to use preimplantation genetic testing for medical or non-medical attributes, stated willingness may not reflect implantation decisions when such information is available. This large cross-national study examined public views on polygenic embryo testing. In a US sample (N = 1,467), participants were more willing to test for medical conditions (for example, heart disease) than non-medical traits (for example, antisocial behaviour or low intelligence), although over half supported testing for non-medical traits. In a forced-choice implantation task, participants used medical and non-medical information to a similar extent when making decisions. Similar patterns were observed in Chinese participants (N = 623). These findings suggest variability in choices across specific traits and conditions, rather than a uniform distinction between medical conditions and non-medical traits. The Stage 1 protocol for this Registered Report was accepted in principle on 7 October 2025. The protocol, as accepted by the journal, can be found at https://osf.io/vb9c2 .