Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis · 2002
Plasma exchange in patients with toxic epidermal necrolysis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bamichas Gerasimos, Natse Taisir, Christidou Fotini, Stangou Maria, Karagianni Anna, Koukourikos Sotiris, Chaidemenos Georgios, Chrysomallis Fotis, Sombolos Kostas
Аннотация
We describe our experience with plasma exchange (PE) therapy in 13 patients with drug-induced toxic epidermal necrolysis (TEN), 4 of whom had malignant disorders. Skin lesions covered 17% to 100% of total body surface area and 1 to 4 mucous membranes were involved. None of the patients was hospitalized in a burn unit. The patients underwent from 2 to 5 PE sessions (mean 3.4 +/- 0.2 standard error of mean [SEM], median 3) exchanging 6.6 to 17.6 L of plasma (mean 10.1 +/- 0.7 SEM, median 10). PE sessions were carried out every other day in 8 patients and daily in 5. Three patients died (23%) while the remaining 10 (77%) had a full recovery. Plasmapheresis may be an effective treatment in patients with drug-induced TEN hospitalized outside a burn unit.