Comparative histological structure of the gastrointestinal mucosa in human and white rat: a bibliographic analysis.

OBJECTIVE

Introduction

According to numerous domestic and foreign researchers, morphofunctional structure of the digestive system of humans and rats have much in common, therefore, rats are used as the laboratory animals during the experiments. The aim of the paper was the comparative study of the histological structure of the gastrointestinal mucosa in human and white rat through the bibliographic analysis of the publications.

PATIENTS AND

METHODS

Materials and methods: The material for the investigation was current publications on the study of the histological structure of the intestine mucosa in human and white rat by analyzing, synthesizing and generalizing the resulting data.

RESULTS

Review and discussion: Histologically, the gastrointestinal mucosa in white rat is similar to the human one. The gastrointestinal mucosa in white rats (with the exception of the generic difference in the structure of the stomach and the caecum), in its histological structure, is quite similar to the human one, to be studied in the experimental simulation of the specific lesions of the digestive system.