Severe staphylococcal scalded skin syndrome.

•Neonate presented with skin scaling and erythema suggestive of congenital ichthyosis.•Clinical features included ectropion, eclabium, and a positive Nikolsky sign.•A diagnosis of SSSS superimposed on congenital ichthyosis was made clinically.•Multidisciplinary care led to skin re-epithelialization and symptom resolution.•Ichthyotic changes persisted despite recovery from acute SSSS episode.