m+Medelevator.RU
← Поиск публикаций
Nature neuroscience · 2024

Integrated multimodal cell atlas of Alzheimer's disease.

СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Gabitto Mariano I, Travaglini Kyle J, Rachleff Victoria M, Kaplan Eitan S, Long Brian, Ariza Jeanelle, Ding Yi, Mahoney Joseph T, Dee Nick, Goldy Jeff, Melief Erica J, Agrawal Anamika, Kana Omar, Zhen Xingjian, Barlow Samuel T, Brouner Krissy, Campos Jazmin, Campos John, Carr Ambrose J, Casper Tamara, Chakrabarty Rushil, Clark Michael, Cool Jonah, Dalley Rachel, Darvas Martin, Ding Song-Lin, Dolbeare Tim, Egdorf Tom, Esposito Luke, Ferrer Rebecca, Fleckenstein Lynn E, Gala Rohan, Gary Amanda, Gelfand Emily, Gloe Jessica, Guilford Nathan, Guzman Junitta, Hirschstein Daniel, Ho Windy, Hupp Madison, Jarsky Tim, Johansen Nelson, Kalmbach Brian E, Keene Lisa M, Khawand Sarah, Kilgore Mitchell D, Kirkland Amanda, Kunst Michael, Lee Brian R, Leytze Mckaila, Mac Donald Christine L, Malone Jocelin, Maltzer Zoe, Martin Naomi, McCue Rachel, McMillen Delissa, Mena Gonzalo, Meyerdierks Emma, Meyers Kelly P, Mollenkopf Tyler, Montine Mark, Nolan Amber L, Nyhus Julie K, Olsen Paul A, Pacleb Maiya, Pagan Chelsea M, Peña Nicholas, Pham Trangthanh, Pom Christina Alice, Postupna Nadia, Rimorin Christine, Ruiz Augustin, Saldi Giuseppe A, Schantz Aimee M, Shapovalova Nadiya V, Sorensen Staci A, Staats Brian, Sullivan Matt, Sunkin Susan M, Thompson Carol, Tieu Michael, Ting Jonathan T, Torkelson Amy, Tran Tracy, Valera Cuevas Nasmil J, Walling-Bell Sarah, Wang Ming-Qiang, Waters Jack, Wilson Angela M, Xiao Ming, Haynor David, Gatto Nicole M, Jayadev Suman, Mufti Shoaib, Ng Lydia, Mukherjee Shubhabrata, Crane Paul K, Latimer Caitlin S, Levi Boaz P, Smith Kimberly A, Close Jennie L, Miller Jeremy A, Hodge Rebecca D, Larson Eric B, Grabowski Thomas J, Hawrylycz Michael, Keene C Dirk, Lein Ed S

Аннотация

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies. This cohort includes 33 male donors and 51 female donors, with an average age at time of death of 88 years. We used quantitative neuropathology to place donors along a disease pseudoprogression score. Pseudoprogression analysis revealed two disease phases: an early phase with a slow increase in pathology, presence of inflammatory microglia, reactive astrocytes, loss of somatostatin+ inhibitory neurons, and a remyelination response by oligodendrocyte precursor cells; and a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb+ and Vip+ inhibitory neuron subtypes. These findings were replicated in other major AD studies.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты