Journal of neurochemistry · 2003
Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line.
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Iurlo Alessandra, Gianelli Umberto, Beghini Alessandro, Spinelli Orietta, Orofino Nicola, Lazzaroni Francesca, Cambiaghi Stefano, Intermesoli Tamara, Rambaldi Alessandro, Cortelezzi Agostino
Аннотация
OBJECTIVE: N-terminal B-type natriuretic peptide (NT-pro-BNP) is secreted from the cardiac ventricles in response to volume expansion and pressure overload, and serum levels are elevated in systolic heart failure. The aim of this study was to evaluate the influence of thyroid function on NT-pro-BNP.
DESIGN: Patients with overt or subclinical thyroid disease were evaluated before and after treatment for their dysthyroid state.
PATIENTS: Seventeen overt and 21 subclinical hypothyroid patients together with six subclinical and 13 overt hyperthyroid patients without cardiac disease were included. Subclinical states had, by definition, free T4 and free T3 estimates within reference ranges.
MEASUREMENTS: Serum levels of NT-pro-BNP and thyroid hormones were measured, and in 31 patients resting cardiac output was measured by impedance cardiography in the untreated state.
RESULTS: NT-pro-BNP levels were more than four times higher in hyperthyroid than hypothyroid patients, with mean values of 30 and 7 pmol/l, respectively (P < 0.001). Serum NT-pro-BNP levels correlated to the thyroid function (vs. free T4 estimate: r = 0.52, P < 0.0001, n = 57). Treatment resulted in significant increases in NT-pro-BNP in both hypothyroid groups, and decreases in both hyperthyroid groups. A multiple linear regression analysis demonstrated that free T4 and free T3 (P < 0.001) estimates were independently associated with a high serum NT-pro-BNP, whereas cardiac output and resting pulse rate were not.
CONCLUSIONS: Serum NT-pro-BNP levels are affected by thyroid function. This seems due to a direct stimulatory effect of thyroid hormones.
DESIGN: Patients with overt or subclinical thyroid disease were evaluated before and after treatment for their dysthyroid state.
PATIENTS: Seventeen overt and 21 subclinical hypothyroid patients together with six subclinical and 13 overt hyperthyroid patients without cardiac disease were included. Subclinical states had, by definition, free T4 and free T3 estimates within reference ranges.
MEASUREMENTS: Serum levels of NT-pro-BNP and thyroid hormones were measured, and in 31 patients resting cardiac output was measured by impedance cardiography in the untreated state.
RESULTS: NT-pro-BNP levels were more than four times higher in hyperthyroid than hypothyroid patients, with mean values of 30 and 7 pmol/l, respectively (P < 0.001). Serum NT-pro-BNP levels correlated to the thyroid function (vs. free T4 estimate: r = 0.52, P < 0.0001, n = 57). Treatment resulted in significant increases in NT-pro-BNP in both hypothyroid groups, and decreases in both hyperthyroid groups. A multiple linear regression analysis demonstrated that free T4 and free T3 (P < 0.001) estimates were independently associated with a high serum NT-pro-BNP, whereas cardiac output and resting pulse rate were not.
CONCLUSIONS: Serum NT-pro-BNP levels are affected by thyroid function. This seems due to a direct stimulatory effect of thyroid hormones.
Предметные рубрики MeSH
AntioxidantsApoptosisCaspasesCell LineDNA FragmentationGene Expression RegulationGlutathioneHumansIn Situ Nick-End LabelingJNK Mitogen-Activated Protein KinasesLeukodystrophy, Globoid CellLipopolysaccharidesMitochondriaMitogen-Activated Protein KinasesNF-kappa BOligodendrogliaOxidation-ReductionPsychosineSignal TransductionTranscription Factor AP-1Transcriptional Activation