A protracted and aggressive variant of lymphocytic hypophysitis with mammillary body involvement and cognitive dysfunction.

OBJECTIVE

Our objective was to describe the 14-year course of a patient with a protracted and aggressive variant of lymphocytic hypophysitis.

METHODS

This is a case report.

RESULTS

Despite several trials of pulse steroids, this young female patient demonstrated persistent inflammation of the pituitary gland with eventual extension into the mammillary bodies with clinical cognitive decline. To our knowledge, there is no other reported case of lymphocytic hypophysitis with autoimmune inflammation extending beyond the infundibulum.

CONCLUSION

This case broadens the clinical spectrum of lymphocytic hypophysitis.