Медицинская библиотека · Pancreas · 2018

The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases.

Strijker Marin, Gerritsen Arja, van Hilst Jony, Bijlsma Maarten F, Bonsing Bert A, Brosens Lodewijk A, Bruno Marco J, van Dam Ronald M, Dijk Frederike, van Eijck Casper H, Farina Sarasqueta Arantza, Fockens Paul, Gerhards Michael F, Groot Koerkamp Bas, van der Harst Erwin, de Hingh Ignace H, van Hooft Jeanin E, Huysentruyt Clément J, Kazemier Geert, Klaase Joost M, van Laarhoven Cornelis J, van Laarhoven Hanneke W, Liem Mike S, de Meijer Vincent E, van Rijssen L Bengt, van Santvoort Hjalmar C, Suker Mustafa, Verhagen Judith H, Verheij Joanne, Verspaget Hein W, Wennink Roos A, Wilmink Johanna W, Molenaar I Quintus, Boermeester Marja A, Busch Olivier R, Besselink Marc G, Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVES

Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter clinical research on pancreatic diseases, including the nationwide multidisciplinary Dutch Pancreatic Cancer Group and Dutch Pancreatitis Study Group. To enable high-quality translational research on pancreatic and periampullary diseases, these groups established the Dutch Pancreas Biobank.

METHODS

The Dutch Pancreas Biobank is part of the Parelsnoer Institute and involves all 8 Dutch university medical centers and 5 nonacademic hospitals. Adult patients undergoing pancreatic surgery (all indications) are eligible for inclusion. Preoperative blood samples, tumor tissue from resected specimens, pancreatic cyst fluid, and follow-up blood samples are collected. Clinical parameters are collected in conjunction with the mandatory Dutch Pancreatic Cancer Audit.

RESULTS

Between January 2015 and May 2017, 488 patients were included in the first 5 participating centers: 4 university medical centers and 1 nonacademic hospital. Over 2500 samples were collected: 1308 preoperative blood samples, 864 tissue samples, and 366 follow-up blood samples.

CONCLUSIONS

Prospective collection of biomaterials and associated clinical data has started in the Dutch Pancreas Biobank. Subsequent translational research will aim to improve treatment decisions based on disease characteristics.

Для цитирования: Strijker Marin, Gerritsen Arja, van Hilst Jony, Bijlsma Maarten F, Bonsing Bert A, Brosens Lodewijk A, Bruno Marco J, van Dam Ronald M, Dijk Frederike, van Eijck Casper H, Farina Sarasqueta Arantza, Fockens Paul, Gerhards Michael F, Groot Koerkamp Bas, van der Harst Erwin, de Hingh Ignace H, van Hooft Jeanin E, Huysentruyt Clément J, Kazemier Geert, Klaase Joost M, van Laarhoven Cornelis J, van Laarhoven Hanneke W, Liem Mike S, de Meijer Vincent E, van Rijssen L Bengt, van Santvoort Hjalmar C, Suker Mustafa, Verhagen Judith H, Verheij Joanne, Verspaget Hein W, Wennink Roos A, Wilmink Johanna W, Molenaar I Quintus, Boermeester Marja A, Busch Olivier R, Besselink Marc G, Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group. The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases.. Pancreas. 2018. DOI: 10.1097/mpa.0000000000001018.

Предметные рубрики MeSH

Academic Medical Centers Aged Ampulla of Vater Biological Specimen Banks Female Humans Male Middle Aged Netherlands Pancreas Pancreatic Neoplasms Prospective Studies Tissue and Organ Procurement Translational Research, Biomedical

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