Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain.
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Rieckmann Nina, Neumann Konrad, Feger Sarah, Ibes Paolo, Napp Adriane, Preuß Daniel, Dreger Henryk, Feuchtner Gudrun, Plank Fabian, Suchánek Vojtěch, Veselka Josef, Engstrøm Thomas, Kofoed Klaus F, Schröder Stephen, Zelesny Thomas, Gutberlet Matthias, Woinke Michael, Maurovich-Horvat Pál, Merkely Béla, Donnelly Patrick, Ball Peter, Dodd Jonathan D, Hensey Mark, Loi Bruno, Saba Luca, Francone Marco, Mancone Massimo, Berzina Marina, Erglis Andrejs, Vaitiekiene Audrone, Zajanckauskiene Laura, Harań Tomasz, Suckiel Malgorzata Ilnicka, Faria Rita, Gama-Ribeiro Vasco, Benedek Imre, Rodean Ioana, Adjić Filip, Čemerlić Adjić Nada, Rodriguez-Palomares José, Garcia Del Blanco Bruno, Brooksbank Katriona, Collison Damien, Davis Gershan, Thwaite Erica, Knuuti Juhani, Saraste Antti, Kępka Cezary, Kruk Mariusz, Benedek Theodora, Ratiu Mihaela, Neskovic Aleksandar N, Vidakovic Radosav, Diez Ignacio, Lecumberri Iñigo, Fisher Michael, Ruzsics Balazs, Hollingworth William, Gutiérrez-Ibarluzea Iñaki, Dewey Marc, Müller-Nordhorn Jacqueline
Аннотация
METHODS: From the pilot study for the European DISCHARGE trial, we analysed data from 24 sites including 1263 patients (45.9% women, 61.1 ± 11.3 years) who were clinically referred for invasive coronary angiography (ICA; 617 patients) or coronary computed tomography angiography (CTA; 646 patients). Prior to the procedures, patients completed HRQoL questionnaires: the Short Form (SF)-12v2, the EuroQoL (EQ-5D-3 L) and the Hospital Anxiety and Depression Scale.
RESULTS: Fifty-five percent of ICA and 35% of CTA patients had typical angina, 23 and 33% had atypical angina, 18 and 28% had non-anginal chest discomfort and 5 and 5% had other chest discomfort, respectively. Patients with typical angina had the poorest physical functioning compared to the other angina groups (SF-12 physical component score; 41.2 ± 8.8, 43.3 ± 9.1, 46.2 ± 9.0, 46.4 ± 11.4, respectively, all age and gender-adjusted p < 0.01), and highest anxiety levels (8.3 ± 4.1, 7.5 ± 4.1, 6.5 ± 4.0, 4.7 ± 4.5, respectively, all adjusted p < 0.01). On all other measures, patients with typical or atypical angina had lower HRQoL compared to the two other groups (all adjusted p < 0.05). HRQoL did not differ between patients with and without obstructive CAD while women had worse HRQoL compared with men, irrespective of age and angina type.
CONCLUSIONS: Prior to a diagnostic procedure for stable chest pain, HRQoL is associated with chest pain characteristics, but not with obstructive CAD, and is significantly lower in women.
TRIAL REGISTRATION: Clinicaltrials.gov, NCT02400229.