Basic fibroblast growth factor treatment for various types of recalcitrant skin ulcers: reports of nine cases.

The treatment of chronic intractable ulcers constitutes crucial topics in dermatological practice. We describe here nine cases of different types of therapy-resistant ulcers that were successfully treated with the employment of spraying with basic fibroblast growth factor once daily. When it was initiated, we could easily find in all the cases that the healing process of the ulcers was greatly accelerated by this therapy with the resultant achievement of complete epithelialization in a relatively short time. This therapeutic modality is useful not only for chronic ulcers but also for acute extensive ulcers.