[Application of autologous platelet-rich gel to refractory chronic diabetic cutaneous ulcers].

OBJECTIVE

To review and evaluate the clinical application of autologous platelet-rich gel (APG) in refractory chronic diabetic cutaneous ulcers.

METHODS

The latest literature was extensively reviewed, and the potential mechanism of APG for healing diabetic cutaneous ulcers was discussed.

RESULTS

APG accelerated the ulcer healing, especially in healing the refractory diabetic cutaneous ulcers, and the high-level growth factors from the platelet releasate were thought to be the major potential mechanism of the APG action.

CONCLUSION

APG can promote the healing of refractory chronic diabetic cutaneous ulcers. Topical haemotherapy with APG may be considered an adjuvant treatment of a multidisciplinary process and may be useful to the effective therapy of cutaneous ulcers.