INFLUENCE OF BETA-BLOCKERS AND IVABRADINE ON LONG-TERM PROGNOSIS OF PATIENTS WITH STABLE ANGINA.

The purpose of the study was to evaluate the influence of beta-blockers and ivabradine on long-term prognosis of patients with stable angina. 90 patients with stable angina that have been involved in present study along with nitrates, antiplatelet agents and statins received bisoprolol (Group I), carvedilol (Group II) and ivabradine (Group III). We analyzed the following indicators: patient adherence to treatment, cases of myocardial infarction and circulatory decompensation, which resulted in necessity of patient's hospitalization during the year of observation, calculating the probability of achieving a key prognostic endpoint by patient using the concept of the odds ratio and determination of important components in the progression of the disease. We concluded that in compared patients groups developed cardiovascular death and unstable angina with almost equal frequency. As for cases of myocardial infarction and the need for revascularization, their number was smaller in patients who in addition to standard treatment received ivabradine. Prognosis of patients with stable angina after 12 months of treatment primarily depends on their adherence to treatment, age, heart rate, presence of harmful habits, and markers of endothelial dysfunction, including endothelin-1 and homocysteine.