Persistent upper gastrointestinal symptoms after Helicobacter pylori eradication: malignant lymphoma following "chicken skin-like" gastritis.

A 37-year-old patient presented to our hospital for upper endoscopy with upper abdominal pain for 10 days. The gastroscopy showed food retention, a large ulcer from the corner of the stomach to the stomach body was seen, the bottom was obviously depressed, the surface was covered by white moss, and the edge of the ulcer presented as a "auricular" sign (Ear-shape appearance). Pathology showed malignant lymphoma. One and a half years prior, the patient underwent a gastroscopy at our hospital. At that time, the gastroscopy showed a large number of nodular protrusions in the gastric antrum, gastric angle, and some parts of the gastric body, presenting a "chicken skin like" change. At the same time, a superficial ulcer lesion was visible in the gastric angle. Pathology suggested gastritis and a small amount of necrotic tissue, as well as proliferation of lymphoid follicles. After receiving the treatment to eradicate Helicobacter pylori (HP), the patient's symptoms significantly improved and no further follow-up was conducted.