Systemic Effect of Thermo-Photobiomodulation on Mesenchymal Stem Cells.

The systemic effects of thermo-photobiomodulation (TPBM) on mesenchymal stem cells (MSCs) and influence of repeated sessions in vivo were studied. The impact of local laser irradiation (λ = 970 nm, moderate power) of rat tibial bone marrow on MSC counts in other bone marrow organs and in the spleen was evaluated. A significant temporary increase in MSCs counts after TPBM was found not only in the irradiated area, but also in distant tissues. Repeated irradiation enhanced MSC growth in the injured area compared to single session, highlighting the potential of repeated TPBM for regulating stem cell activity. These findings open prospects for developing new cell therapy methods aimed at accelerating tissue and organ regeneration.