Effect of GT-Peptide 10 and Triethyl Citrate on <em>P. acnes</em> Biofilm Formation, Viability, and Dispersion.

BACKGROUND

P. acnes biofilms are emerging topics in acne vulgaris pathogenesis and may be responsible for antibiotic tolerance.<br/>

OBJECTIVE

To investigate the efficacy of GT peptide 10 either alone or in combination with triethyl citrate (TEC) in in vitro model of P. acnes biofilm.<br/>

METHODS

Six-day-old P. acnes biofilms were treated with various concentrations of these substances and biofilm dispersion and cell viability were monitored.<br/>

RESULTS

A 24-hour exposure of preformed biofilms to a combination of GT peptide 10/TEC led to killing of up to 92% of bacterial cells inside the biofilm. Neither the single substance nor the combination of both substances affected the biofilm integrity or resulted in biofilm dispersal.<br/>

CONCLUSIONS

A combination of GT peptide 10/TEC shows antibacterial effects in in vitro model of P. acnes biofilm. <br /><br /> <em>J Drugs Dermatol. </em>2016;15(6):778-781.