Histological differentiation between sporadic and colitis-associated intestinal cancer in a nationwide study: A propensity-score-matched analysis.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Uchino Motoi, Ikeuchi Hiroki, Noguchi Tatsuki, Okabayashi Koji, Futami Kitaro, Tanaka Shinji, Ohge Hiroki, Watanabe Kazuhiro, Itabashi Michio, Okamoto Kinya, Okita Yoshiki, Mizushima Tsunekazu, Mizuuchi Yusuke, Yamada Kazutaka, Shimada Yoshifumi, Sato Yu, Kimura Hideaki, Takahashi Kenichi, Hida Koya, Kinugasa Yusuke, Okuda Junji, Daito Koji, Koyama Fumikazu, Ueno Hideki, Yamamoto Takayuki, Hanai Tsunekazu, Kono Toru, Kobayashi Hirotoshi, Ajioka Yoichi, Sugihara Kenichi, Ishihara Soichiro, Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers of the Japanese Society for Cancer of the Colon and Rectum
Аннотация
METHODS: We reviewed the clinical and histological data collected from a nationwide database in Japan between 1983 and 2020. Patient characteristics were compared to distinguish ulcerative colitis (UC), Crohn's disease (CD), and sporadic CRC. Comparisons were performed by using all collected data and propensity score-matched data.
RESULTS: A total of 1077 patients with UC-CAC, 297 with CD-CAC, and 136 927 with sporadic CRC were included. Although the prevalence of well or moderately differentiated adenocarcinoma (Tub1 and Tub2) decreased according to tumor progression for all diseases (P < 0.01), the prevalence of other histological findings, including signet ring cell carcinoma, mucinous carcinoma, poorly differentiated adenocarcinoma, or squamous cell carcinoma, was significantly higher in CAC than in sporadic CRC. Based on propensity score-matched data for 982 patients with UC and 268 with CD, the prevalence of histological findings other than Tub1 and Tub2 was also significantly higher in those with CAC. At pT4, mucinous carcinoma occurred at a significantly higher rate in patients with CD (45/86 [52.3%]) than in those with sporadic CRC (13/88 [14.8%]) (P < 0.01).
CONCLUSION: CAC, including early-stage CAC, has a higher malignant grade than sporadic CRC, and this difference increases in significance with tumor progression.