Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma.
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Stevens Jennifer S, Harnett Nathaniel G, Lebois Lauren A M, van Rooij Sanne J H, Ely Timothy D, Roeckner Alyssa, Vincent Nico, Beaudoin Francesca L, An Xinming, Zeng Donglin, Neylan Thomas C, Clifford Gari D, Linnstaedt Sarah D, Germine Laura T, Rauch Scott L, Lewandowski Christopher, Storrow Alan B, Hendry Phyllis L, Sheikh Sophia, Musey Paul I, Haran John P, Jones Christopher W, Punches Brittany E, Lyons Michael S, Kurz Michael C, McGrath Meghan E, Pascual Jose L, Datner Elizabeth M, Chang Anna M, Pearson Claire, Peak David A, Domeier Robert M, O'Neil Brian J, Rathlev Niels K, Sanchez Leon D, Pietrzak Robert H, Joormann Jutta, Barch Deanna M, Pizzagalli Diego A, Sheridan John F, Luna Beatriz, Harte Steven E, Elliott James M, Murty Vishnu P, Jovanovic Tanja, Bruce Steven E, House Stacey L, Kessler Ronald C, Koenen Karestan C, McLean Samuel A, Ressler Kerry J
Аннотация
METHODS: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments.
RESULTS: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms.
CONCLUSIONS: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.