Phytotherapy research : PTR · 2007
Evaluation of antiviral activity of South American plant extracts against herpes simplex virus type 1 and rabies virus.
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Müller Vanessa, Chávez Juliana H, Reginatto Flávio H, Zucolotto Silvana M, Niero Rivaldo, Navarro Dionezine, Yunes Rosendo A, Schenkel Eloir P, Barardi Célia R M, Zanetti Carlos R, Simões Cláudia M O
Аннотация
This paper describes the screening of different South American plant extracts and fractions. Aqueous and organic extracts were prepared and tested for antiherpetic (HSV-1, KOS and 29R strains) and antirabies (PV strain) activities. The evaluation of the potential antiviral activity of these extracts was performed by using an MTT assay for HSV-1, and by a viral cytopathic effect (CPE) inhibitory method for rabies virus (RV). The results were expressed as 50% cytotoxicity (CC(50)) for MTT assay and 50% effective (EC(50)) concentrations for CPE, and with them it was possible to calculate the selectivity indices (SI = CC(50)/EC(50)) of each tested material. From the 18 extracts/fractions tested, six extracts and four fractions showed antiviral action. Ilex paraguariensis, Lafoensia pacari, Passiflora edulis, Rubus imperialis and Slonea guianensis showed values of SI > 7 against HSV-1 KOS and 29-R strains and Alamanda schottii showed a SI of 5.6 against RV, PV strain.