Microbes and infection · 2006
Role of GPI-anchored NCAM-120 in rabies virus infection.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Hotta Kozue, Motoi Yurie, Okutani Akiko, Kaku Yoshihiro, Noguchi Akira, Inoue Satoshi, Yamada Akio
Аннотация
Although the neural cell adhesion molecule (NCAM) -140 and -180 have been shown to serve as a receptor for rabies virus (RV), it was not known whether the other major isoform of NCAM, GPI-anchored NCAM-120 functions as RV receptor. In this study, we have established HEp-2 cells stably expressing NCAM-120 or NCAM-140, and their susceptibilities to RV infection were compared. The results demonstrated that NCAM-120 served as virus attachment protein; however, the cells expressing NCAM-120 did not support efficient RV replication. Furthermore, the level of IFN-ss mRNA was apparently elevated in NCAM-120 expressing cells but not in NCAM-140 expressing cells, suggesting that GPI-anchored NCAM-120 suppressed RV replication via induction of IFN-ss even though NCAM-120 was able to promote virus penetration into the cells.