[ORGAN-SPECIFIC AND ORGAN-NONESPECIFIC AUTOANTIBODIES AND DAMAGE OF ORGANS AND SYSTEMS AT SJOGREN'S SYNDROME].

The aim of the study was to determine the presence of various organ-specific and organ - nonspecific autoantibodies and their association with Sjogren's syndrome - one of the most pervasive autoimmune disorders that affects entire body. The etiology of Sjogren's syndrome is not clearly understood. It may be due combination of factors: inherited, hormonal, infection from virus. 21 patients were examined, all women, mean age 53.5±0.9 years. Everyone was conducted clinical, laboratory and instrumental trial, definition of existence of antinuclear antibodies, a rhematoid factor, antibodies to antigens of a thyroid gland, smooth muscles, parietal cells of a stomach, antigens of sial glands and alpha- fodrin. In addition to SS- A and SS - B antibodies and a rheumatoid factor there are characteristic of Sjogren's syndrome, were revealed antibodies to the native and denatured DNA, antigens of a thyroid gland, stomach, smooth muscles, neutrophilic leukocytes, sial glands. It was found that in addition to a clinical manifestations Sjogren's syndrome is characterized by existence of a wide range of organ-specific and organ- nonspecific autoantibodies that is a consequence of polyclonal uncontrollable activation of the immune system. Existence of autoantibodies is associated with features of a course of a disease, existence of damage of organs and systems and requires individual treatment.