Longitudinal analysis of meibomian gland dropout in patients with ocular graft-versus-host disease.

PURPOSE: To evaluate morphological changes in meibomian glands (MGs) over 1 year in patients diagnosed with chronic ocular graft-versus-host disease (GVHD), and to determine the association between MG loss and ocular surface parameters in such patients.

METHODS

This retrospective, observational study included 37 patients diagnosed with ocular GVHD who were followed-up for at least 1 year in the ophthalmology department. All patients received treatment during the follow-up period. The Ocular Surface Disease Index (OSDI) score, tear breakup time (TBUT), corneal staining score, lid margin score, Schirmer test I value, and noncontact infrared meibography findings were evaluated at baseline and after 1 year of follow-up for ocular GVHD. Both eyes were included in the analyses.

RESULTS

OSDI (p = 0.0391), corneal fluorescein scores (p = 0.0352 and 0.0181 for the right and left eyes, respectively), and upper and lower eyelid meiboscores (right eye: p = 0.0039 and 0.0156, respectively: left eye: p = 0.0273 and 0.0156, respectively) were significantly higher at 1 year than at baseline. Infrared meibography showed MG loss in 18.9% of eyes, improvement in 5.4% of eyes, and no changes in 75.7% of eyes, respectively. The Schirmer value for the right eye negatively correlated with the upper eyelid meiboscore at 1 year (p = 0.0103, r = -0.46), whereas the corneal fluorescein score for the left eye positively correlated with both upper and lower eyelid meiboscores at 1 year (p = 0.0368, r = 0.40; p = 0.0387, r = 0.39, respectively).

CONCLUSIONS

Rapid and aggressive MG destruction may occur in patients with ocular GVHD. Further studies with larger patient samples and longer follow-up periods are mandatory to validate these conclusions.