[Various compensatory and adaptive changes in the exocrine function of the pancreas in chronic primary gastroduodenitis].

A study was made of external secretory pancreatic function in 167 patients with chronic primary gastroduodenitis (CPGD), 64 with duodenal ulcer (DU) and 10 healthy persons using a method of endogenous and exogenous (in some of the patients) stimulation with secretin and pancreozymin. The phasic nature of these disturbances was revealed. At early stages it manifested itself in an increase in the volume of juice production and bicarbonate debit, later on-in a decrease in bicarbonate excretion with a tendency to an increase in amylase and trypsin activity, in a prolonged course--in a progressive decrease in bicarbonate excretion and activity of one or two enzymes. Correlations of clinical signs with endoscopic and histological changes in the gastric mucosa, disturbances of the biliferous tracts were noted. More significant reversibility of deviations revealed during treatment in CPGD as compared to duodenal ulcer was established. The authors recommended that the disturbances revealed should be taken into account in the course of therapy and prophylaxis.