[Application of iodine staining in transoral laser microsurgery for early glottic carcinoma].

Objective

To evaluate the value of iodine staining in the margin determination in transoral laser microsurgery for early glottic carcinoma. Method:35 patients with early glottic laryngeal cancer（Tis-T2） were enrolled in this study from January 2016 to December 2017.All patients were applied with 1.5% Lugol iodine solution to vocal cords for 3 times after general anesthesia，and the coloration of the laryngeal cavity was observed under the operation microscope to determine the lesion margins.The lesions were excised completely with CO₂ laser.The complications，complete resection rate and recurrence rate were evaluated. Result:In all patients，iodine staining was used to assist in determining the lesion range during transoral laser microsurgery.None of the patients had complications.Postoperative pathological results showed that the complete resection rate was 88.6%.There were no local recurrence cases in Tis and T1a，while local recurrence rate was 12.5% in T1b and 16.7% in T2，respectively.The overall local recurrence rate was 5.7%.

Conclusion

The application of iodine staining in transoral laser microsurgery for early glottic carcinoma may help improve the complete resection rate and local control rate.It is a reliable，simple and low-cost method，worthy of further clinical application.Key words: laryngeal neoplasms;glottis; transoral laser microsurgery; iodine staining.