Dermatology (Basel, Switzerland) · 2011
The anti-inflammatory drug colchicine lacks efficacy in hidradenitis suppurativa.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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van der Zee H H, Prens E P
Аннотация
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease. Since current treatments are unsatisfactory for many patients, there is a high need for effective drugs for this debilitating disease. Recent pathogenic insights suggest inflammasome activation and IL-1β production are important in HS. Colchicine is efficacious in the IL-1β- and inflammasome-mediated diseases gout, familial Mediterranean fever and Behçet's disease, and therefore a potentially effective drug in HS.
OBJECTIVE: To investigate the efficacy of colchicine in HS.
METHODS: In an open prospective pilot study, 8 HS patients were treated with the accepted gout maintenance regimen of 0.5 mg colchicine b.i.d. orally up to 4 months. Efficacy was assessed by a physician global assessment.
RESULTS: Colchicine treatment did not result in a clinically relevant improvement of disease severity. Three patients experienced nausea and diarrhea as known side effects.
CONCLUSION: Colchicine in the used dose regimen does not ameliorate HS severity.
OBJECTIVE: To investigate the efficacy of colchicine in HS.
METHODS: In an open prospective pilot study, 8 HS patients were treated with the accepted gout maintenance regimen of 0.5 mg colchicine b.i.d. orally up to 4 months. Efficacy was assessed by a physician global assessment.
RESULTS: Colchicine treatment did not result in a clinically relevant improvement of disease severity. Three patients experienced nausea and diarrhea as known side effects.
CONCLUSION: Colchicine in the used dose regimen does not ameliorate HS severity.