Dermatology (Basel, Switzerland) · 2009
The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa.
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van der Zee Hessel H, Boer Jurr, Prens Errol P, Jemec Gregor B E
Аннотация
BACKGROUND: A previous limited study showed promising results of combined oral treatment with rifampicin 600 mg and clindamycin 600 mg for 10 weeks.
OBJECTIVE: To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations.
METHOD: A retrospective study in 34 patients.
RESULTS: Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease.
CONCLUSION: Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established.
OBJECTIVE: To expand and to validate the basis for this therapy, we reviewed the response to different treatment durations.
METHOD: A retrospective study in 34 patients.
RESULTS: Twenty-eight of 34 patients (82%) experienced at least partial improvement, and 16 (47%) showed a total remission. The maximum effect of treatment appeared within 10 weeks. Following total remission, 8 of 13 (61.5%) patients treated as mentioned above experienced a relapse after a mean period of 5.0 months. Nonresponders were predominantly patients with severe disease.
CONCLUSION: Combination treatment with oral rifampicin and clindamycin is a promising treatment option for hidradenitis suppurativa, despite the frequent occurrence of diarrhea as a side effect. The length and the dosage of treatment are not yet firmly established.
Предметные рубрики MeSH
Administration, OralAdultClindamycinCohort StudiesDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesHidradenitis SuppurativaHumansMaleMiddle AgedPatient SatisfactionQuality of LifeRetrospective StudiesRifampinSeverity of Illness IndexTreatment OutcomeYoung Adult