Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2014
[The clinical heterogenity of Parkinson's disease].
Аннотация на английскомСтатьяНазвание и аннотация: Оригинал на русском
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Miliukhina I V, Karpenko M N, Timofeeva A A, Skoromets A A
Аннотация
OBJECTIVE: To identify clinical signs that determine a phenotypic heterogeneity of idiopathic Parkinson's disease (PD) using cluster analysis.
MATERIAL AND METHODS: Cluster analysis was applied to main clinical signs characteristic of disease course and to the results of examination of 72 PD patients based on 5 scales.
RESULTS: Clinical signs that determine a phenotypic heterogeneity of PD were identified. The most significant variables were a form of disease, predominance of akinetic/rigid syndrome or tremor syndrome as well as the age at disease onset, severity of motor deficit and autonomic symptoms.
CONCLUSION: The definition "a form of PD" has a wider meaning compared to established one. To determine a form of disease, we recommend to consider both the predominance of a definite motor symptom and a set of additional clinical parameters.
MATERIAL AND METHODS: Cluster analysis was applied to main clinical signs characteristic of disease course and to the results of examination of 72 PD patients based on 5 scales.
RESULTS: Clinical signs that determine a phenotypic heterogeneity of PD were identified. The most significant variables were a form of disease, predominance of akinetic/rigid syndrome or tremor syndrome as well as the age at disease onset, severity of motor deficit and autonomic symptoms.
CONCLUSION: The definition "a form of PD" has a wider meaning compared to established one. To determine a form of disease, we recommend to consider both the predominance of a definite motor symptom and a set of additional clinical parameters.