Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014
Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients.
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Ciancarelli Irene, De Amicis Daniela, Di Massimo Caterina, Di Scanno Carla, Pistarini Caterina, D'Orazio Nicolantonio, Tozzi Ciancarelli Maria Giuliana
Аннотация
CONTEXT: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).
MATERIALS AND METHODS: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.
RESULTS: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.
DISCUSSION AND CONCLUSION: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
MATERIALS AND METHODS: Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.
RESULTS: Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.
DISCUSSION AND CONCLUSION: Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.