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DOI 10.3109/1354750x.2014.935955

Медицинская библиотека · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2014

Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients.

Ciancarelli Irene, De Amicis Daniela, Di Massimo Caterina, Di Scanno Carla, Pistarini Caterina, D'Orazio Nicolantonio, Tozzi Ciancarelli Maria Giuliana

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

CONTEXT: Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).

MATERIALS AND

METHODS

Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.

RESULTS

Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.

DISCUSSION AND

CONCLUSION

Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.

Для цитирования: Ciancarelli Irene, De Amicis Daniela, Di Massimo Caterina, Di Scanno Carla, Pistarini Caterina, D'Orazio Nicolantonio, Tozzi Ciancarelli Maria Giuliana. Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2014. DOI: 10.3109/1354750x.2014.935955.

Предметные рубрики MeSH

8-Hydroxy-2'-DeoxyguanosineAdultBiomarkersCase-Control StudiesDeoxyguanosineFemaleHumansHuntington DiseaseMaleMiddle AgedOxidative StressPhosphopyruvate HydrataseSuperoxide Dismutase
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