Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia.
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Gonzalez Maria Camila, Tovar-Rios Diego Alejandro, Alves Guido, Dalen Ingvild, Williams-Gray Caroline H, Camacho Marta, Forsgren Lars, Bäckström David, Lawson Rachael A, Macleod Angus D, Counsell Carl E, Paquet Claire, DeLena Carlo, D'Antonio Fabrizia, Pilotto Andrea, Padovani Alessandro, Blanc Frédéric, Falup-Pecurariu Cristian, Lewis Simon J G, Rejdak Konrad, Papuc Ewa, Hort Jakub, Nedelska Zuzana, O'Brien John, Bonanni Laura, Marquié Marta, Boada Mercè, Pytel Vanesa, Abdelnour Carla, Alcolea Daniel, Beyer Katrin, Tysnes Ole-Bjørn, Aarsland Dag, Maple-Grødem Jodi
Аннотация
OBJECTIVES: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.
METHODS: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157).
RESULTS: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (-1.8 [95% CI -2.3, -1.3] vs. -1.9 [95% CI -2.6, -1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]).
CONCLUSIONS: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.