Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022
[An infrequent cause of cholestasis: morphine-induced cholestasis].
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Canullan Carlos, Du Plessis María Cristina, Merchan Del Hierro Pablo, Quesada Bernabe, Petracchi Enrique
Аннотация
INTRODUCTION: Extrahepatic cholestasis by opiates is a very rare entity of which only case reports are recorded in the literature.
METHODS: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying disease, treated by laparoscopic surgery.
RESULTS: The patient evolved favorably in the postoperative period without bilirrhage and was discharged on the fifth day with bilirubin values within normal parameters.
CONCLUSION: Sphincter of Oddi dysfunction syndrome secondary to long-term use of opioids is a very rare entity. However, it should be suspected in cases of extrahepatic cholestasis in which no stones or tumors are observed and in patients with long-term use of high-dose opiates either due to addiction or chronic pain treatment.
METHODS: We present the case of a patient who developed abdominal pain and cholestasis after consumption of high doses of morphine for pain management of her underlying disease, treated by laparoscopic surgery.
RESULTS: The patient evolved favorably in the postoperative period without bilirrhage and was discharged on the fifth day with bilirubin values within normal parameters.
CONCLUSION: Sphincter of Oddi dysfunction syndrome secondary to long-term use of opioids is a very rare entity. However, it should be suspected in cases of extrahepatic cholestasis in which no stones or tumors are observed and in patients with long-term use of high-dose opiates either due to addiction or chronic pain treatment.