Heliyon · 2024
Cytokine Storm among Bangladeshi adults with COVID-19: A prospective cohort study.
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Sarmin Monira, Akter Fhameda, Islam Anika Nawrin, Mahfuz Mustafa, Das Subhasish, Sharifuzzaman, Hasan S M Tafsir, Bhuiyan Taufiqur Rahman, Rahman Mustafizur, Gazi Amran, Matin Fariha Bushra, Tariqujjaman Md, Shahrin Lubaba, Islam Mofakharul, Mahmud Asif Mujtaba, Banu Sayera, Chisti Mohammod Jobayer, Qadri Firdausi, Clemens John David, Ahmed Tahmeed
Аннотация
OBJECTIVE: In COVID-19, cytokine storms (CS) result in higher mortality and morbidity. Our study evaluated the rate of cytokine storms among COVID-positive Bangladeshi adults.
METHODS: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults. COVID-positive cases were treated in a makeshift COVID unit of icdr,b Dhaka Hospital. CS was defined as having IL-6 >80 pg/mL or any three of the following: high CRP, ferritin, LDH, D-dimer, or low lymphocyte. Stored plasma samples were tested for the cytokines IL-6, IL-1β, and TNF-α.
RESULTS: This study involved 77 participants, 32 were in the severe-critical group, 30 were in the mild-moderate group, and 14 were COVID-negative. Twelve participants in the severe-critical group had CS. Thus, the rate of CS was 37.5 % (12/32). Compared to COVID-19-negative patients, COVID-19-positive patients had higher IL-6 levels, which decreased at discharge except for those dying. Among the COVID-19-positive patients, nine died. For both the mild-moderate and severe-critical patients, IL-6 increased with increasing CRP (p < 0.001).
CONCLUSION: During the COVID-19 pandemic, Bangladeshi adults experienced a surge in cytokine storms. The rate of cytokine storm in Bangladeshi COVID-19-positive adults was 37.5 %.
METHODS: From October 2020 to March 2022, this cohort study enrolled both COVID-positive and COVID-negative healthy adults. COVID-positive cases were treated in a makeshift COVID unit of icdr,b Dhaka Hospital. CS was defined as having IL-6 >80 pg/mL or any three of the following: high CRP, ferritin, LDH, D-dimer, or low lymphocyte. Stored plasma samples were tested for the cytokines IL-6, IL-1β, and TNF-α.
RESULTS: This study involved 77 participants, 32 were in the severe-critical group, 30 were in the mild-moderate group, and 14 were COVID-negative. Twelve participants in the severe-critical group had CS. Thus, the rate of CS was 37.5 % (12/32). Compared to COVID-19-negative patients, COVID-19-positive patients had higher IL-6 levels, which decreased at discharge except for those dying. Among the COVID-19-positive patients, nine died. For both the mild-moderate and severe-critical patients, IL-6 increased with increasing CRP (p < 0.001).
CONCLUSION: During the COVID-19 pandemic, Bangladeshi adults experienced a surge in cytokine storms. The rate of cytokine storm in Bangladeshi COVID-19-positive adults was 37.5 %.