Topical treatment of onychomycosis with efinaconazole solution 10%.

Onychomycosis, a common nail infection that often is associated with substantial patient distress, disability, and pain, is a challenge to manage successfully. This report presents the case of a 44-year-old man with moderate distallateral subungual onychomycosis (DLSO) of more than 5 years' duration and discusses effective treatment with efinaconazole solution 10%, a new topical antifungal, once daily for 48 weeks. At baseline, 50% of the great toenail was affected and laboratory test results were positive for Trichophyton rubrum. Mycologic cure was noted at week 36 with complete cure observed at the end of treatment (week 48). This case demonstrates for physicians that efinaconazole solution 10% is a promising new topical treatment of onychomycosis and emphasizes the importance of mycologic cure as an early indicator of treatment success.