Protocol for mapping frequency-specific information transfer between cortical areas using ECoG and Granger causality.

This protocol details the application of Granger causality (GC) analysis to primate electrocorticography (ECoG) data to map frequency-specific information transfer. We describe steps for computing pairwise GC and generating spatial GC maps, including differential maps to isolate task-specific activity. We then explain how to perform hierarchical clustering on GC patterns to identify and visualize the spatial distribution of functional electrode clusters, revealing the organization of information flow. For complete details on the use and execution of this protocol, please refer to Zhou et al.1.