Indian journal of pharmacology · 2015
Gamma activity model for treatment-resistant bipolar psychotic mania.
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Kumar Shashi Ranjan, Sinha Vinod Kumar, Tikka Sai Krishna, Goyal Nishant
Аннотация
OBJECTIVES: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
METHODS: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.
RESULTS: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
CONCLUSIONS: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
METHODS: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.
RESULTS: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
CONCLUSIONS: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.