Journal of the renin-angiotensin-aldosterone system : JRAAS · 2014
Association of polymorphisms in AGTR1 and AGTR2 genes with primary aldosteronism in the Chinese Han population.
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Wu Zhun, Huang Chao, Zhou Tingting, Lin Jinglai, Zhang Kaiyan, Li Wei, Zheng Jiaxin, Chen Bin, Wang Baojun, Zhang Xu, Xing Jinchun
Аннотация
HYPOTHESIS: Polymorphisms in angiotensin II type-1/2 receptor genes (AGTR1/AGTR2) may be involved in the pathogenesis of primary aldosteronism. The present study aims to reveal some loci susceptible to the disease on the genes in a group of Chinese Han nationality.
MATERIALS AND METHODS: A case-control study was conducted in 202 patients and 188 controls. Ten tagging SNPs on AGTR1/AGTR2 were genotyped for all subjects via the method of multiplex PCR-ligase detection reaction. Statistical analysis was performed with chi-square test and logistic regression analysis.
RESULTS: rs3772616 on the AGTR1 gene was a factor for susceptibility to primary aldosteronism (p<0.001), and the TT genotype significantly decreased the risk of primary aldosteronism compared with the CC homozygote (p=0.008, adjusted OR=0.13; 95%CI: 0.03-0.59). The rs3772616 polymorphism was associated with primary aldosteronism under the additive and dominant models. The female carriers of the G allele in rs5193 showed a significant difference compared with the T allele.
CONCLUSIONS: The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women.
MATERIALS AND METHODS: A case-control study was conducted in 202 patients and 188 controls. Ten tagging SNPs on AGTR1/AGTR2 were genotyped for all subjects via the method of multiplex PCR-ligase detection reaction. Statistical analysis was performed with chi-square test and logistic regression analysis.
RESULTS: rs3772616 on the AGTR1 gene was a factor for susceptibility to primary aldosteronism (p<0.001), and the TT genotype significantly decreased the risk of primary aldosteronism compared with the CC homozygote (p=0.008, adjusted OR=0.13; 95%CI: 0.03-0.59). The rs3772616 polymorphism was associated with primary aldosteronism under the additive and dominant models. The female carriers of the G allele in rs5193 showed a significant difference compared with the T allele.
CONCLUSIONS: The AGTR1 rs3772616 polymorphism can be considered as a hereditary marker for primary aldosteronism, and in the Chinese Han population the rs5193 G allele seems to predispose to it only in women.
Предметные рубрики MeSH
AllelesAsian PeopleCase-Control StudiesEthnicityFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansHyperaldosteronismLinkage DisequilibriumMaleMiddle AgedModels, GeneticOdds RatioPolymorphism, Single NucleotideReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2