Clinical biochemistry · 2014
Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential hypertension.
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Chang Yi-Yao, Lee Hsiu-Hao, Hung Chi-Sheng, Wu Xue-Ming, Lee Jen-Kuang, Wang Shuo-Meng, Liao Min-Tsun, Chen Ying-Hsien, Wu Vin-Cent, Wu Kwan-Dun, Lin Yen-Hung, TAIPAI Study Group
Аннотация
OBJECTIVE: To investigate the association between aldosterone and cardiac diastolic dysfunction.
DESIGN AND METHODS: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.
RESULTS: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.
CONCLUSIONS: Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
DESIGN AND METHODS: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.
RESULTS: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.
CONCLUSIONS: Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.