Hepatology research : the official journal of the Japan Society of Hepatology · 2011
Smoking, family history and urinary tract infection are associated with primary biliary cirrhosis: A meta-analysis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liang Yan, Yang Zaixing, Zhong Renqian
Аннотация
AIM: This meta-analysis was conducted to provide more precise evidence for association between primary biliary cirrhosis (PBC) and smoking and some other factors.
METHODS: We searched the databases PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure up to 31 December 2010. Data were extracted by two persons independently. Homogeneity of effects across studies was assessed using the χ(2) -test statistic and quantified by I(2) . Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- or random-effects models. The publication bias was analyzed by Egger and Begg tests.
RESULTS: A total of five studies were selected according to inclusion criteria. With the fixed-effects model, the pooled OR for PBC and smoking and family history of PBC were 1.67 (95% CI = 1.41-1.92) and 7.56 (95% CI = 1.90-13.22). With the random-effects model, the pooled OR for thyroid disease and urinary tract infection (UTI) were 3.08 (95% CI = 0.84-5.32) and 2.02 (95% CI = 1.40-2.65), respectively. No evidence of publication bias was observed by means of Begg and Egger tests for the factors.
CONCLUSION: This meta-analysis suggested that smoking, family history of PBC and UTI were strongly associated with PBC in a white population by systematic review of five existing studies, and the association remains to be validated in other populations.
METHODS: We searched the databases PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure up to 31 December 2010. Data were extracted by two persons independently. Homogeneity of effects across studies was assessed using the χ(2) -test statistic and quantified by I(2) . Odds ratio (OR) and 95% confidence intervals (CI) were calculated based on fixed- or random-effects models. The publication bias was analyzed by Egger and Begg tests.
RESULTS: A total of five studies were selected according to inclusion criteria. With the fixed-effects model, the pooled OR for PBC and smoking and family history of PBC were 1.67 (95% CI = 1.41-1.92) and 7.56 (95% CI = 1.90-13.22). With the random-effects model, the pooled OR for thyroid disease and urinary tract infection (UTI) were 3.08 (95% CI = 0.84-5.32) and 2.02 (95% CI = 1.40-2.65), respectively. No evidence of publication bias was observed by means of Begg and Egger tests for the factors.
CONCLUSION: This meta-analysis suggested that smoking, family history of PBC and UTI were strongly associated with PBC in a white population by systematic review of five existing studies, and the association remains to be validated in other populations.