International journal of nanomedicine · 2020
Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property.
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Zheng Mian-Hong, Bigdeli Fahime, Gao Lan-Xing, Wu Deng-Ze, Yan Xiao-Wei, Hu Mao-Lin, Morsali Ali
Аннотация
AIM: A new Ag(I) complex (A3) was synthesized and evaluated for its anticancer activity against human cancer cell lines.
MATERIALS AND METHODS: The complex A3 was characterized by 1H, 13C, and 31P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples.
RESULTS: The interaction mode of the complex A3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations.
CONCLUSION: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.
MATERIALS AND METHODS: The complex A3 was characterized by 1H, 13C, and 31P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples.
RESULTS: The interaction mode of the complex A3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations.
CONCLUSION: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.