Life (Basel, Switzerland) · 2025
Invisible Links: Associations Between Micronutrient Deficiencies and Postpartum Depression-A Systematic Review.
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Voros Charalampos, Sapantzoglou Ioakeim, Athanasiou Diamantis, Mavrogianni Despoina, Bananis Kyriakos, Athanasiou Antonia, Athanasiou Aikaterini, Papadimas Georgios, Tsimpoukelis Charalampos, Gkirgkinoudis Athanasios, Papapanagiotou Ioannis, Vaitsis Dimitrios, Koulakmanidis Aristotelis-Marios, Ivanidou Sofia, Stepanyan Anahit J, Daskalaki Maria Anastasia, Thomakos Nikolaos, Theodora Marianna, Antsaklis Panagiotis, Chatzinikolaou Fotios, Loutradis Dimitrios, Daskalakis Georgios
Аннотация
BACKGROUND: Following childbirth, up to 20% of women may have postpartum depression (PPD), which can adversely affect the mother's health, the infant's development, and familial connections. Numerous causes exist, although recent research indicates that micronutrient shortages are modifiable biological factors. This systematic review aims to consolidate existing knowledge regarding the relationship between micronutrient levels and the risk of PPD.
METHODS: This review was conducted in accordance with PRISMA 2020 guidelines and registered with PROSPERO. We reviewed every study published up to 1 April 2025, on PubMed, Scopus, and Web of Science. Nineteen studies met the inclusion criteria. We employed the Newcastle-Ottawa Scale to assess bias.
RESULTS: Nineteen studies were included in the analysis. Vitamin D was the most extensively researched vitamin. The majority of the studies (9 out of 13) identified a significant correlation between low serum 25(OH)D levels and PPD symptoms. Individuals with diminished levels of vitamin B12 and zinc had an elevated risk of PPD. There was insufficient evidence for folate, magnesium, iron, and selenium. This was frequently due to methodological discrepancies, insufficient control of confounding variables, and variations in biomarker timing. The majority of the studies exhibit a low to moderate likelihood of bias.
CONCLUSIONS: Increasing evidence suggests that deficiencies in specific micronutrients, particularly vitamin D, vitamin B12, and zinc, may contribute to the onset of postpartum depression. The results indicate that targeted nutritional screening and management may be beneficial in perinatal mental health care, notwithstanding the inability to ascertain the exact causative factors. There is a necessity for more rigorous longitudinal investigations and randomised trials to enhance our understanding of processes and assist physicians in making informed judgements.
METHODS: This review was conducted in accordance with PRISMA 2020 guidelines and registered with PROSPERO. We reviewed every study published up to 1 April 2025, on PubMed, Scopus, and Web of Science. Nineteen studies met the inclusion criteria. We employed the Newcastle-Ottawa Scale to assess bias.
RESULTS: Nineteen studies were included in the analysis. Vitamin D was the most extensively researched vitamin. The majority of the studies (9 out of 13) identified a significant correlation between low serum 25(OH)D levels and PPD symptoms. Individuals with diminished levels of vitamin B12 and zinc had an elevated risk of PPD. There was insufficient evidence for folate, magnesium, iron, and selenium. This was frequently due to methodological discrepancies, insufficient control of confounding variables, and variations in biomarker timing. The majority of the studies exhibit a low to moderate likelihood of bias.
CONCLUSIONS: Increasing evidence suggests that deficiencies in specific micronutrients, particularly vitamin D, vitamin B12, and zinc, may contribute to the onset of postpartum depression. The results indicate that targeted nutritional screening and management may be beneficial in perinatal mental health care, notwithstanding the inability to ascertain the exact causative factors. There is a necessity for more rigorous longitudinal investigations and randomised trials to enhance our understanding of processes and assist physicians in making informed judgements.