Probiotics and antimicrobial proteins · 2024
In Vitro and In Vivo Anti-Candida albicans Activity of a Scorpion-Derived Peptide.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Li Zhongjie, Shui Yingbin, Wang Huayi, Li Shasha, Deng Bo, Zhang Wenlu, Gao Shegan, Zhao Lingyu
Аннотация
The increasing infection and drug resistance frequency has encouraged the exploration of new and effective anti-Candida albicans agents. In this study, CT-K3K7, a scorpion antimicrobial peptide derivative, effectively inhibit the growth of C. albicans. CT-K3K7 killed C. albicans cells in a dose-dependent manner, mainly by damaging the plasma membrane. CT-K3K7 could also disrupt the nucleus and interact with nucleic acid. Moreover, CT-K3K7 induced C. albicans cells necrosis via a reactive oxygen species (ROS)-related pathway. Furthermore, CT-K3K7 inhibited the hyphal and biofilm formation of C. albicans. In the mouse skin subcutaneous infection model, CT-K3K7 significantly prevented skin abscess formation and reduced the number of C. albicans cells recovered from the infection area. Taken together, CT-K3K7 has the potential to be a therapeutic for C. albicans skin infections.