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Nature genetics · 2019

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

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Warrington Nicole M, Beaumont Robin N, Horikoshi Momoko, Day Felix R, Helgeland Øyvind, Laurin Charles, Bacelis Jonas, Peng Shouneng, Hao Ke, Feenstra Bjarke, Wood Andrew R, Mahajan Anubha, Tyrrell Jessica, Robertson Neil R, Rayner N William, Qiao Zhen, Moen Gunn-Helen, Vaudel Marc, Marsit Carmen J, Chen Jia, Nodzenski Michael, Schnurr Theresia M, Zafarmand Mohammad H, Bradfield Jonathan P, Grarup Niels, Kooijman Marjolein N, Li-Gao Ruifang, Geller Frank, Ahluwalia Tarunveer S, Paternoster Lavinia, Rueedi Rico, Huikari Ville, Hottenga Jouke-Jan, Lyytikäinen Leo-Pekka, Cavadino Alana, Metrustry Sarah, Cousminer Diana L, Wu Ying, Thiering Elisabeth, Wang Carol A, Have Christian T, Vilor-Tejedor Natalia, Joshi Peter K, Painter Jodie N, Ntalla Ioanna, Myhre Ronny, Pitkänen Niina, van Leeuwen Elisabeth M, Joro Raimo, Lagou Vasiliki, Richmond Rebecca C, Espinosa Ana, Barton Sheila J, Inskip Hazel M, Holloway John W, Santa-Marina Loreto, Estivill Xavier, Ang Wei, Marsh Julie A, Reichetzeder Christoph, Marullo Letizia, Hocher Berthold, Lunetta Kathryn L, Murabito Joanne M, Relton Caroline L, Kogevinas Manolis, Chatzi Leda, Allard Catherine, Bouchard Luigi, Hivert Marie-France, Zhang Ge, Muglia Louis J, Heikkinen Jani, EGG Consortium, Morgen Camilla S, van Kampen Antoine H C, van Schaik Barbera D C, Mentch Frank D, Langenberg Claudia, Luan Jian'an, Scott Robert A, Zhao Jing Hua, Hemani Gibran, Ring Susan M, Bennett Amanda J, Gaulton Kyle J, Fernandez-Tajes Juan, van Zuydam Natalie R, Medina-Gomez Carolina, de Haan Hugoline G, Rosendaal Frits R, Kutalik Zoltán, Marques-Vidal Pedro, Das Shikta, Willemsen Gonneke, Mbarek Hamdi, Müller-Nurasyid Martina, Standl Marie, Appel Emil V R, Fonvig Cilius E, Trier Caecilie, van Beijsterveldt Catharina E M, Murcia Mario, Bustamante Mariona, Bonas-Guarch Sílvia, Hougaard David M, Mercader Josep M, Linneberg Allan, Schraut Katharina E, Lind Penelope A, Medland Sarah E, Shields Beverley M, Knight Bridget A, Chai Jin-Fang, Panoutsopoulou Kalliope, Bartels Meike, Sánchez Friman, Stokholm Jakob, Torrents David, Vinding Rebecca K, Willems Sara M, Atalay Mustafa, Chawes Bo L, Kovacs Peter, Prokopenko Inga, Tuke Marcus A, Yaghootkar Hanieh, Ruth Katherine S, Jones Samuel E, Loh Po-Ru, Murray Anna, Weedon Michael N, Tönjes Anke, Stumvoll Michael, Michaelsen Kim F, Eloranta Aino-Maija, Lakka Timo A, van Duijn Cornelia M, Kiess Wieland, Körner Antje, Niinikoski Harri, Pahkala Katja, Raitakari Olli T, Jacobsson Bo, Zeggini Eleftheria, Dedoussis George V, Teo Yik-Ying, Saw Seang-Mei, Montgomery Grant W, Campbell Harry, Wilson James F, Vrijkotte Tanja G M, Vrijheid Martine, de Geus Eco J C N, Hayes M Geoffrey, Kadarmideen Haja N, Holm Jens-Christian, Beilin Lawrence J, Pennell Craig E, Heinrich Joachim, Adair Linda S, Borja Judith B, Mohlke Karen L, Eriksson Johan G, Widén Elisabeth E, Hattersley Andrew T, Spector Tim D, Kähönen Mika, Viikari Jorma S, Lehtimäki Terho, Boomsma Dorret I, Sebert Sylvain, Vollenweider Peter, Sørensen Thorkild I A, Bisgaard Hans, Bønnelykke Klaus, Murray Jeffrey C, Melbye Mads, Nohr Ellen A, Mook-Kanamori Dennis O, Rivadeneira Fernando, Hofman Albert, Felix Janine F, Jaddoe Vincent W V, Hansen Torben, Pisinger Charlotta, Vaag Allan A, Pedersen Oluf, Uitterlinden André G, Järvelin Marjo-Riitta, Power Christine, Hyppönen Elina, Scholtens Denise M, Lowe William L, Davey Smith George, Timpson Nicholas J, Morris Andrew P, Wareham Nicholas J, Hakonarson Hakon, Grant Struan F A, Frayling Timothy M, Lawlor Debbie A, Njølstad Pål R, Johansson Stefan, Ong Ken K, McCarthy Mark I, Perry John R B, Evans David M, Freathy Rachel M

Аннотация

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты