Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients.

BACKGROUND

Activation of immunological and systemic inflammation markers are common in obesity and asthma.

OBJECTIVE

The target of this study was to assess impact of weight reduction on immunological and systemic inflammation markers in obese asthma patients.

MATERIAL AND

METHODS

Eighty asthmatic patients of both sex; their age and body mass index (BMI) mean were 38.72 ± 7.14 year and 32.65 ± 3.18 Kg/m2 respectively. Exclusion criteria included smokers, infections, vaccinations, cancer, surgery, immune system disorders and medications that may influence immune system function as anti-inflammatory medications, analgesics and anti-depressant. All subjects were randomly enrolled in weight reduction group (group A) or control group (group B).

RESULTS

The main findings in the present study indicated that weight reducing program in group (A) was associated with significant reduction in the mean values of IL6, TNF-α, and IL8 in addition to significant increase in the mean values of CD4 and CD8 cell count . However, findings of group (B) showed no significant changes. Moreover, Comparison between both groups at the end of the study revealed significant differences.

CONCLUSION

Weight reduction improved immunological and systemic inflammation markers in obese asthma patients.