Temporal trends of waitlistings for liver transplantation in Italy: The ECALITA (Evolution of IndiCAtion in LIver transplantation in ITAly) registry study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Manzia Tommaso Maria, Trapani Silvia, Nardi Alessandra, Ricci Andrea, Lenci Ilaria, Milana Martina, Angelico Roberta, De Feo Tullia Maria, Agnes Salvatore, Andorno Enzo, Baccarani Umberto, Carraro Amedeo, Cescon Matteo, Cillo Umberto, Colledan Michele, De Carlis Luciano, De Simone Paolo, Di Benedetto Fabrizio, Ettorre Giuseppe Maria, Gruttadauria Salvatore, Lupo Luigi Giovanni, Mazzaferro Vincenzo, Romagnoli Renato, Rossi Giorgio, Rossi Massimo, Spada Marco, Vennarecci Giovanni, Vivarelli Marco, Zamboni Fausto, Tisone Giuseppe, Cardillo Massimo, Angelico Mario
Аннотация
AIM: To investigate how the indications for elective adult liver transplantation and the underlying disease etiologies have evolved in Italy.
METHODS: We recruited from the National Transplant Registry a cohort comprising 17,317 adults patients waitlisted for primary liver transplantation from January-2004 to December-2020. Patients were divided into three Eras:1(2004-2011),2(2012-2014) and 3(2015-2020).
RESULTS: Waitlistings for cirrhosis decreased from 65.9% in Era 1 to 46.1% in Era 3, while those for HCC increased from 28.7% to 48.7%. Comparing Eras 1 and 3, waitlistings for HCV-related cirrhosis decreased from 35.9% to 12.1%, yet those for HCV-related HCC increased from 8.5% to 26.7%. Waitlistings for HBV-related cirrhosis remained almost unchanged (13.2% and 12.4%), while those for HBV-related HCC increased from 4.0% to 11.6%. ALD-related cirrhosis decreased from 16.9% to 12.9% while ALD-related HCC increased from 1.9% to 3.9%.
CONCLUSIONS: A sharp increase in liver transplant waitlisting for HCC and a concomitant decrease of waitlisting for cirrhosis have occurred In Italy. Despite HCV infection has noticeably decreased, still remains the primary etiology of waitlisting for HCC, while ALD and HBV represent the main causes for cirrhosis.