Characteristics and survival of patients with primary biliary cholangitis and hepatocellular carcinoma.
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История · было → стало
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Giannini Edoardo G, Pieri Giulia, Labanca Sara, Plaz Torres Maria Corina, Gasbarrini Antonio, Biasini Elisabetta, Campani Claudia, Cazzagon Nora, Foschi Francesco Giuseppe, Mega Andrea, Masotto Alberto, Raimondo Giovanni, Rapaccini Gian Ludovico, Sacco Rodolfo, Caturelli Eugenio, Guarino Maria, Tovoli Francesco, Vidili Gianpaolo, Brunetto Maurizia Rossana, Nardone Gerardo, Svegliati-Baroni Gianluca, Magalotti Donatella, Azzaroli Francesco, Cabibbo Giuseppe, Di Marco Maria, Sangiovanni Angelo, Trevisani Franco, Italian Liver Cancer (ITA.LI.CA) Study Group
Аннотация
AIM: To describe main characteristics and outcome of PBC patients with HCC diagnosed in the new millennium.
METHODS: Analysing the Italian Liver Cancer registry we identified 80 PBC patients with HCC diagnosed after the year 2000, and described their clinical characteristics, access to treatment and survival.
RESULTS: Median age of patients was 71 years and 50.0% were males. Cirrhosis was present in 86.3% of patients, being well-compensated in 58.0%. Median HCC diameter was smaller in patients under surveillance (2.6 vs 4.0 cm, P = 0.007). Curative treatment, feasible in 50.0% of patients, was associated with improved survival compared to palliative and supportive care (42 vs 33 vs 6 months, P<0.0001). Surveillance was associated with a non-significant improved survival (36 vs 23 months), likely due to similar rate of curative treatment in patients under (51.4%) and outside surveillance (42.6%).
CONCLUSIONS: PBC patients with HCC are often elderly males with well-preserved liver function. Feasibility of curative treatment is high and associated with improved prognosis. Description of these patients may help focus surveillance to identify earlier tumours, increase their curability, and improve prognosis.